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- W2372883485 abstract "Objective To study the expression of vascular endothelial growth factor(VEGF), microvessel density (MVD) and the relationship among angiogenesis,proliferation,and apoptosis in colorectal cancer (CRC). Methods Expression of VEGF mRNA was evaluated by semi quantitative RT PCR in 52 CRC samples and 48 adjacent normal colorectal tissue samples. The PCR product was sequenced to verify the desired results. Expressions of VEGF protein, MVD, proliferating index (PI), and apoptotic index (AI) were detected by immunohistochemical methods in 52 human CRC. Results Expression of VEGF mRNA was detected in a significantly greater proportion of colorectal carcinoma samples than that adjacent normal colorectal tissues (76.9% vs. 52.1%; P 0.01). The expression of VEGF mRNA in CRC correlated with distant metastasis and Dukes' stage, of which Dukes' stage D was significantly higher than that Dukes' stage A and B( P 0.01). The PCR product of VEGF shared 98% of homology with human counterpart. VEGF expression was observed immunohistochemically in 29 of 52 cases of colorectal carcinoma(55.8%). MVD was significantly higher in VEGF positive group than that in VEGF negative group (21.1±8.2 vs. 13.9±5.0, P 0.01 ) and the PI was greater in VEGF positive group than that in VEGF negative group (56%±21% vs. 42%±16%, P 0.05), but the difference of AI between VEGF positive group and VEGF negative group was not significant (0.86%±0.42% vs. 0.95%±0.36%; P 0.05). The expression of VEGF protein was positively correlated with PI ( r =0.409, P 0.01) and MVD( r =0.539, P 0.01),but not correlated with AI( r =-0.264, P 0.05). Conclusions VEGF may play an important role in the angiogenesis of colorectal carcinoma and cell proliferation, but may not directly correlate with cell apoptosis." @default.
- W2372883485 created "2016-06-24" @default.
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- W2372883485 date "2004-01-01" @default.
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- W2372883485 title "Angiogenesis in colorectal cancer and its relationship with apoptosis and proliferation" @default.
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