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• W2372885488 abstract "The association between topographic patterns, risk factors and stroke mechanisms of ICAS in first-ever stroke remains unknown.A large sample sized retrospective study was performed on first-ever ICAS ischemic stroke using DWI and MRA.Hypertension (60.92%), cigarette smoking (26.82%), MCA (76.65%) and multiple vessels (65.37%) stenosis, were the major factors favoring different mechanisms. Subcortical lesions were the most occurring topographic patterns (41.4%). The common mechanism was LBO (66.3%). Statistical analysis showed a significant relationship between lesion patterns and mechanisms (r = 0.384, P = 0.001). Single mechanism had the higher apoB/apoAI ratio (P = 0.005) and levels of plasma apoB (P = 0.007) compared with multiple mechanisms. The anterior circulation stroke were more multiple mechanisms as compared to the posterior circulation stroke (P = 0.001). LBO was more prevalent in posterior circulation stroke than in anterior circulation stroke (P = 0.001).The topographic patterns of ischemic lesions is helpful in early identification of different mechanisms of ICAS. Monitoring apoB and apoB/apoA1 may help to predict the mechanism of stroke with ICAS. The prevalence of mechanisms differ between anterior and posterior circulation stroke with ICAS." @default.
• W2372885488 created "2016-06-24" @default.
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• W2372885488 date "2016-06-02" @default.
• W2372885488 modified "2023-09-25" @default.
• W2372885488 title "Risk factors, topographic patterns and mechanism analysis of intracranial atherosclerotic stenosis ischemic stroke" @default.
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• W2372885488 doi "https://doi.org/10.1080/00207454.2016.1188298" @default.
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