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- W2372887350 abstract "AIM To investigate the effects of all trans retinoic acid in combination with phenylacete natrium on human hepatocellular carcinoma (HCC) cell line SMMC 7721. METHODS HCC cell line was exposed to all trans retinoic acid and phenylacete natrium separately and both agents in combining manner respectively. The morphologic and functional changes of the cell line were observed with benzo blue, MTT, flow cytometric analysis, image analysis and AFPmeasurement. RESULTS Single all trans retinoic acid or phenylacete natrium could inhibite the proliferation of human HCC cell line (SMMC 7721), which had obvious dose and time effect. After SMMC 7721 cells were treated with combined treatment of both agents for 7 d, the suppression rate was about 66.5%. The malignant phenotype of the cell line gradually disappeared while characteristics of mature cell were progressively increased. The secretory volume of AFP was reduced by 49.2%. The cells at G 0/G 1 phase were relatively increased by 58.7% and synthesis of DNA inhibited by 35.8% ( P 0.05). CONCLUSION The combined use of the two agents can inhibit proliferation and induce differentiation in the HCC cell more significantly than any other agent." @default.
- W2372887350 created "2016-06-24" @default.
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- W2372887350 date "2002-01-01" @default.
- W2372887350 modified "2023-09-23" @default.
- W2372887350 title "Effects of all-trans retinoic acid with phenylacete natrium on human HCC cell line" @default.
- W2372887350 hasPublicationYear "2002" @default.
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