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- W2372907247 abstract "Objective To explore the effect of genistein pharmacological post-treatment on the cardiocyte apoptosis,pathomorphology and ultrastructural changes of myocardial tissue in rats with ischemia-reperfusion injury.Methods Forty rats were randomized into 5 groups:sham group,ischemia-reperfusion group and 0.1,1.0,5.0 mg/kg genistein post-treatment groups.The pathological and the ultrastructural changes of cardiac muscle were observed under light microscope and electron microscope,respectively.The apoptosis index was determined using TUNEL,and the activity of caspase-3 was detected.Results The apoptosis index and the activity of caspase-3 significantly decreased in genistein post-treatment groups compared with ischemia-reperfusion group.In genistein post-treatment groups,the pathomorphology and ultrastructure of myocardium tissue showed the most serious injury in 5.0 mg/kg genistein post-treatment group,and the lightest in 1.0 mg/kg genistein post-treatment group.Conclusion Genistein pharmacological post-treatment has a protective effect on ischemia-reperfusion injury in rats,which may be induced by the inhibition of cardiocyte apoptosis.The protective effect is related to the dosage." @default.
- W2372907247 created "2016-06-24" @default.
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- W2372907247 date "2009-01-01" @default.
- W2372907247 modified "2023-09-24" @default.
- W2372907247 title "Effect of genistein pharmacological post-treatment on cardiomyocyte apoptosis and ultrastructure of myocardial tissue in rats with ischemia-reperfusion injury" @default.
- W2372907247 hasPublicationYear "2009" @default.
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