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- W2372918105 abstract "Objective To investigate the early pathological and behavioral changes in APP/PS1 transgenic Alzheimer's disease(AD) mouse model.Methods Five-or seven-month-old amyloid precursor protein/presenilin 1(APP/PS1) transgenic mice and non-transgenic mice were chosen as the experimental animals.The relationship of cerebral amyloid plaques accumulation with spatial learning and memory ability of mice with different months old was studied by using Congo red staining and quantitative methods combined with the Morris water maze behavioral test.Results(1) There was significant difference of special learning and memory ability between 7-month-old APP/PS1 transgenic mice and non-transgenic mice(P0.05).(2) The results of Congo red staining showed that jacinth plaques were presented in the cerebral cortex and hippocampus of 5-and 7-month-old APP/PS1 transgenic mice while was not found in non-transgenic mice.Conclusion Learning and memory ability is decreased in 7-month-old APP / PS1 transgenic mice,and the early appearance of amyloid plaques in cerebral cortex and hippocampus of APP / PS1 transgenic mice is age-dependent.The results will provide reference data for the evaluation of therapeutic effect of early intervention of AD." @default.
- W2372918105 created "2016-06-24" @default.
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- W2372918105 date "2012-01-01" @default.
- W2372918105 modified "2023-09-23" @default.
- W2372918105 title "Early Changes of Pathology and Cognitive Behavior in APP/PS1 Transgenic Mice with Alzheimer's Disease" @default.
- W2372918105 hasPublicationYear "2012" @default.
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