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• W2372919190 abstract "Objective To investigate the perioperative myocardial protective action of dexmedetomidine in gastrointestinal cancer patients treated by intraoperative peritoneal hyperthermic chemotherapy(IPHC).Methods A total of 48 gastrointestinal cancer patients were selected in Handan Centeral Hospital from May 2014 to May 2015,all of them received gastrointestinal cancer radical operation and IPHC.According to random number table,all of the patients were divided into D1 group,D2 group and C group,each of 16 cases.Before anesthesia induction,patients of D1 group and D2 group received intravenous pumping of dexmedetomidine(1 μg / kg); after anesthesia induction,patients of D1 group received uniform intravenous pumping of dexmedetomidine(0.5 μg · kg-1· h-1),while patients of D2 group received uniform intravenous pumping of dexmedetomidine(0.2 μg · kg-1·h-1).Patients of C group received same amount of intravenous pumping of0.9% sodium chloride injection.Hemodynamic index(including HR,MAP and Sp O2)before 10 minutes of IPHC,after 30 minutes and 60 minutes of IPHC,after 30 minutes of the end of IPHC was compared among the three groups,respectively;myocardial enzymological index(including serum levels of CK-MB and c Tn I)before 10 minutes of IPHC,after 30 minutes,24 hours and 60 minutes of IPHC,after 30 minutes,24 hours and 72 hours of the end of IPHC was compared among the three groups,respectively.Results No statistically significant differences of HR or MAP was found among the three groups before 10 minutes of IPHC,nor was Sp O2 among the three groups before 10 minutes of IPHC,after 30 minutes or 60 minutes of IPHC,or after 30 minutes of the end of IPHC(P 0.05); after 30 minutes,24 hours and 60 minutes of IPHC,after 30 minutes of the end of IPHC,HR of D1 group,D2 group was statistically significantly lower than that of C group,respectively,MAP of D1 groupwas statistically significantly lower than that of C,respectively(P 0.05); MAP of D2 group was statistically significantly lower than that of C group after 60 minutes of IPHC(P 0.05).No statistically significant differences of serum CK-MB level was found among the three groups before 10 minutes of IPHC,after 60 minutes of IPHC or after 72 hours of the end of IPHC(P 0.05); after 30 minutes and 24 hours of the end of IPHC,serum CK-MB level of D1 group,D2 group was statistically significantly lower than that of C group,respectively,serum CK-MB level of D1 was statistically significantly lower than that of D2 group(P 0.05).No statistically significant differences of serum c Tn I level was found among the three groups before 10 minutes of IPHC or after 60 minutes of IPHC(P 0.05); after 30 minutes,24 hours and 72 hours of the end of IPHC,serum c Tn I level of D1 group,D2 group was statistically significantly lower than that of C group,respectively(P 0.05); after 30 minutes and 24 hours of the end of IPHC,serum c Tn I level of D1 group was statistically significantly lower than that of D2 group,respectively(P 0.05).Conclusion Dexmedetomidine has some perioperative myocardial protective action in gastrointestinal cancer patients treated by IPHC,and large-dose dexmedetomidine has better perioperative myocardial protective action." @default.
• W2372919190 created "2016-06-24" @default.
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• W2372919190 date "2015-01-01" @default.
• W2372919190 modified "2023-09-28" @default.
• W2372919190 title "Perioperative Myocardial Protective Action of Dexmedetomidine in Gastrointestinal Cancer Patients Treated by Intraoperative Peritoneal Hyperthermic Chemotherapy" @default.
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