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- W2372941889 abstract "Objective To identify the relationship of decreased focal cerebral ischemia/reperfusion injury by VEGF in rabbits and the expression of cysteinyl aspirate-specific proteinase-3(caspase-3) protein.Methods Focal cerebral ischemia/reperfusion model was induced.The VEGF was administered at 0,1 and 3 h after reperfusion respectively.Infarct and edema volumes,neurological deficit score,apoptotic cells,and expression of caspase-3 were assessed at 3 d after reperfusion.Results VEGF reduced infarct volumes as compared with controls by 23.3% and 17.9% when administered VEGF at 0 and 1 h after reperfusion.Edema volumes,apoptotic cells and expression of caspase-3 in the perifocal regions were significantly lower than that of control group when administered VEGF within 1 h after reperfusion(P0.01).No difference was found when administered VEGF at 3 h after reperfusion.Infarct volumes were significantly correlated with expression of caspase-3 in the perifocal regions(P0.05).Conclusion The effect of VEGF on the expression of caspase-3 is related with the neuroprotective time window.The VEGF can reduce the incidence of neuronal apoptosis during the cerebral ischemia/reperfusion injury by reducing the expression of caspase-3 protein." @default.
- W2372941889 created "2016-06-24" @default.
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- W2372941889 date "2009-01-01" @default.
- W2372941889 modified "2023-09-26" @default.
- W2372941889 title "VEGF alleviates cerebral ischemia/reperfusion injury and the results in expression of caspase-3 in rabbits" @default.
- W2372941889 hasPublicationYear "2009" @default.
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