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- W2372945557 abstract "OBJECTIVE To study the protective effect of minocycline on beta-amyloid protein 25-35(Aβ25-35)-induced toxicity in cultured rat cortical neurons.METHODS The toxicity model was established by treated neurons with Aβ25-35 in cultured rat cortical neurons.Cell death was determined by the release of cellular lactate dehydrogenase (LDH). Apoptosis was evaluated by Hoechest 33258 staining and DNA gel electrophoresis.The activity of caspase3 was assayed by fluorescent substrat.RESULTS Minocycline reduced the level of LDH in the medium of the neurons treated with Aβ25-35 and kept the survival of neurons.Aβ25-35 induced nuclic condensation and DNA fragment in neurons at 24 h.These effects were attenuated by minocycline.In addition,the activity of caspase3 was increased in neurons after treated with Aβ25-35. The activity of caspase3 was inhibited.CONCLUSION Minocycline inhibited Aβ25-35-induced apoptosis in cultured cortical neurons.The effects of minocycline might be through inhibiting the activation of caspase3 induced by Aβ25-35." @default.
- W2372945557 created "2016-06-24" @default.
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- W2372945557 date "2003-01-01" @default.
- W2372945557 modified "2023-09-24" @default.
- W2372945557 title "Preliminary study on minocycline against β-amyloid protein 25-35-induced toxicity in vitro" @default.
- W2372945557 hasPublicationYear "2003" @default.
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