Matches in SemOpenAlex for { <https://semopenalex.org/work/W2372946893> ?p ?o ?g. }
Showing items 1 to 55 of
55
with 100 items per page.
- W2372946893 abstract "Objective To investigate the effects of ligustrazine on inflammatory reaction and postoperative cognitive function in elderly patients undergoing open- heart surgery. Methods 40 patients undergoing cardiac single valve replacement surgery with cardiopulmonary bypass( CPB) in the First Hospital of Ningbo form March 2012 to April 2013 were randomly divided into two groups. Group A( n = 20) : patients received ligustrazine 3 mg / kg before anesthesia induction by jugular vein injection was instilled within 20 minutes,and 3 mg / kg was added to the priming solution. Group B( n = 20) : the same dose of saline was used. The plasmatic hs- CRP,IL- 6,IL- 10 was determined before CPB( T1),after CBP( T2),2 h after surgery( T3),24 h after surgery( T4) and 72 h after surgery( T5). Cognitive function of patients was evaluated by MMSE 1 d before operation( t1),1 d after operation( t2) and 3 d after operation( t3). Results The plasmatic hs- CRP,IL- 6,IL- 10 of patients in two groups at each time point of T2 to T5 was significantly higher than that at T1 point( P 0. 05); compared with that of Group B,the plasmatic hs- CRP and IL- 6 of Group A at time point of T2 to T5 was lower( P 0. 05) and the plasmatic IL- 10 at time point of T2 to T3 was higher( P 0. 05). The MMSE score of patients in two groups at each time point of t2 and t3 were significantly lower than that at t1 point( P 0. 05),postoperative cognition of patients in two groups was impaired after surgery. Compared to that of patients in Group B,the MMSE score of patients in Group A at time point of t2 and t3 were higher( P 0. 05). The incidence of POCD of patients in Group A at time point of t2 and t3 was 5( 25%) and 3( 15%) respectively,and the incidence of POCD in Group B at time point of t2 and t3 was 8( 40%) and 7( 35%),there was no significantdifference( P 0. 05). Conclusion Ligustrazine can decrease the degree of the impairment of the postoperative cognition in elderly patients undergoing open- heart surgery and promote its improvement." @default.
- W2372946893 created "2016-06-24" @default.
- W2372946893 creator A5062332980 @default.
- W2372946893 date "2014-01-01" @default.
- W2372946893 modified "2023-09-24" @default.
- W2372946893 title "Effects of Ligustrazine on Inflammatory Reaction and Postoperative Cognitive Function in Elderly Patients Undergoing Open-heart Surgery" @default.
- W2372946893 hasPublicationYear "2014" @default.
- W2372946893 type Work @default.
- W2372946893 sameAs 2372946893 @default.
- W2372946893 citedByCount "0" @default.
- W2372946893 crossrefType "journal-article" @default.
- W2372946893 hasAuthorship W2372946893A5062332980 @default.
- W2372946893 hasConcept C118552586 @default.
- W2372946893 hasConcept C141071460 @default.
- W2372946893 hasConcept C169900460 @default.
- W2372946893 hasConcept C2777397205 @default.
- W2372946893 hasConcept C2778881276 @default.
- W2372946893 hasConcept C2780043718 @default.
- W2372946893 hasConcept C42219234 @default.
- W2372946893 hasConcept C71924100 @default.
- W2372946893 hasConceptScore W2372946893C118552586 @default.
- W2372946893 hasConceptScore W2372946893C141071460 @default.
- W2372946893 hasConceptScore W2372946893C169900460 @default.
- W2372946893 hasConceptScore W2372946893C2777397205 @default.
- W2372946893 hasConceptScore W2372946893C2778881276 @default.
- W2372946893 hasConceptScore W2372946893C2780043718 @default.
- W2372946893 hasConceptScore W2372946893C42219234 @default.
- W2372946893 hasConceptScore W2372946893C71924100 @default.
- W2372946893 hasLocation W23729468931 @default.
- W2372946893 hasOpenAccess W2372946893 @default.
- W2372946893 hasPrimaryLocation W23729468931 @default.
- W2372946893 hasRelatedWork W2407564335 @default.
- W2372946893 hasRelatedWork W2467477237 @default.
- W2372946893 hasRelatedWork W2589807363 @default.
- W2372946893 hasRelatedWork W3025695833 @default.
- W2372946893 hasRelatedWork W3028862838 @default.
- W2372946893 hasRelatedWork W3029120156 @default.
- W2372946893 hasRelatedWork W3029136355 @default.
- W2372946893 hasRelatedWork W3029254757 @default.
- W2372946893 hasRelatedWork W3029332020 @default.
- W2372946893 hasRelatedWork W3029619055 @default.
- W2372946893 hasRelatedWork W3029761952 @default.
- W2372946893 hasRelatedWork W3030240399 @default.
- W2372946893 hasRelatedWork W3030347461 @default.
- W2372946893 hasRelatedWork W3031323807 @default.
- W2372946893 hasRelatedWork W3031415374 @default.
- W2372946893 hasRelatedWork W3031673527 @default.
- W2372946893 hasRelatedWork W3031937187 @default.
- W2372946893 hasRelatedWork W3032154770 @default.
- W2372946893 hasRelatedWork W3032229144 @default.
- W2372946893 hasRelatedWork W3032708089 @default.
- W2372946893 isParatext "false" @default.
- W2372946893 isRetracted "false" @default.
- W2372946893 magId "2372946893" @default.
- W2372946893 workType "article" @default.