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- W2372958866 abstract "Objective To investigate the clinical significance of the detection of serum lipid,lipoprotein-α[Lp(α)],uric acid(UA),β2-microglobulinandhigh(β2-MG)and high sensitivity C-reactive protein(hs-CRP)in coronary atherosclerosis patients with chronic heart failure.Methods From January 2014 to December 2014,268 cases of coronary atherosclerosis patients with chronic heart failure and 30 cases of coronary atherosclerosis patients without heart failure were collected in Renmin Hospital of Wuhan University.The levels of serum lipid,Lp(α),UA,β2-MG and hsCRP were detected,and the differences of the indicators between coronary atherosclerosis patients with different cardiac functional grades.Results Among coronary atherosclerosis patients with different cardiac functional grades,there was no differences of serum liquid and Lp(α)levels(P0.05).The levels of UA,β2-MG and hs-CRP increased with the cardiac functional grade(F=3.841,10.241 and 4.065,P0.05).The pairwise comparison of UA,β2-MG and hs-CRP showed thatβ2-MG and hs-CRP levels of patients with cardiac functional grade Ⅱ were significantly higher than those of patients with cardiac functional gradeⅠ(t=-3.358,-3.513,P0.05);patients with cardiac functional gradeⅢ had significantly higherβ2-MG and hs-CRP levels than patients with cardiac functional grade Ⅱ(t=-5.298,-4.666,P0.05);and patients with cardiac functional gradeⅣ had significantly higher UA,β2-MG and hs-CRP levels than patients with cardiac functional gradeⅢ(t=-2.777,-4.386,-2.222,P0.05).Pearson correlation analysis showed thatβ2-MG was negatively correlated with TG(r=-0.534,P0.05),hs-CRP was positively correlated with TC,TG,LDL-C(r=0.790,0.608,0.753,P0.05)in patients with cardiac functional gradeⅠ;β2-MG was positively correlated with UA and hs-CRP(r=0.409 and 0.420,P0.05)in patients with cardiac functional gradeⅡ;β2-MG was negatively correlated with HDL-C(r=-0.302,P0.05),and positively correlated with UA(r=0.388,P0.05)in patients with cardiac functional grade Ⅲ;β2-MG was positively correlated with TG and hs-CRP(r=0.623,0.502,P0.05),and hs-CRP was negatively correlated with HDL-C(r=-0.543,P0.05)in patients with cardiac functional gradeⅣ.Conclusion Combined detection of serum UA,β2-MG and hs-CRP can dynamically monitor the heart function of patients with coronary atherosclerosis and provide a reasonable reference for the treatment and prognosis." @default.
- W2372958866 created "2016-06-24" @default.
- W2372958866 creator A5035580149 @default.
- W2372958866 date "2015-01-01" @default.
- W2372958866 modified "2023-09-24" @default.
- W2372958866 title "Significance of combined detection of three indicators in coronary atherosclerosis patients with chronic heart failure" @default.
- W2372958866 hasPublicationYear "2015" @default.
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