Matches in SemOpenAlex for { <https://semopenalex.org/work/W2372965651> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2372965651 abstract "Objective To investigate the effect of sorafenib and epirubicin(EPI) on the proliferation of breast carcer MCF-7 cells and its probable mechanism.Methods MTT assay was utilized to detect the light absorbance(A) from day 1 to 14 to determine growth kinetics.Giemsa was utilized to detect the cloning efficiency of MCF-7 cells.The IC50 of sorafenib and EPI was assessed after the MCF-7 cells incubated for 24,48,72 h.The best concentration and time of coadministration was decided acorrding to the IC50 results.Four different groups were set up,they were control group,sorafenib group,EPI group,sorafenib+EPI group.The inhibitory effects of sorafenib,EPI and sorafenib+EPI treatment on MCF-7 proliferation in vitro were assessed by MTT assay after incubated for 72 h.Results The growth curve showed that the growth velocity of MCF-7 cells was fast at the first 4 days,but slowed down 5 days after,and stayed at a standstill in last stage.The cloning efficiency of MCF-7 cells was 37.2%.The IC50 of Sorafenib at 24,48,72 h are(7.85±0.86),(3.45±0.16),(2.10±0.64)μmol/L,the IC50 of EPI at 24,48,72 h were(6.52±0.62),(1.61±0.82),(1.13±0.51)μmol/L.Sorafenib and EPI both significantly inhibited the proliferation of MCF-7 cells at 72 h,showiong a synergistic effect of their actions in combined use(P0.05).In the combination group,the inhibition rate increased as the concentration of administration increased(P0.05).Conclusion Sorafenib and EPI have synergistic effects in inhibiting the proliferation of MCF-7 cells." @default.
- W2372965651 created "2016-06-24" @default.
- W2372965651 creator A5056813172 @default.
- W2372965651 date "2010-01-01" @default.
- W2372965651 modified "2023-09-28" @default.
- W2372965651 title "Effects of sorafenib and epirubicin on the proliferation of breast carcer MCF-7 cell in vitro and its mechanism" @default.
- W2372965651 hasPublicationYear "2010" @default.
- W2372965651 type Work @default.
- W2372965651 sameAs 2372965651 @default.
- W2372965651 citedByCount "0" @default.
- W2372965651 crossrefType "journal-article" @default.
- W2372965651 hasAuthorship W2372965651A5056813172 @default.
- W2372965651 hasConcept C109541995 @default.
- W2372965651 hasConcept C121608353 @default.
- W2372965651 hasConcept C126322002 @default.
- W2372965651 hasConcept C153911025 @default.
- W2372965651 hasConcept C185592680 @default.
- W2372965651 hasConcept C202751555 @default.
- W2372965651 hasConcept C2777752497 @default.
- W2372965651 hasConcept C2778019345 @default.
- W2372965651 hasConcept C2778695046 @default.
- W2372965651 hasConcept C2779707156 @default.
- W2372965651 hasConcept C2780783641 @default.
- W2372965651 hasConcept C2780835546 @default.
- W2372965651 hasConcept C2994423619 @default.
- W2372965651 hasConcept C530470458 @default.
- W2372965651 hasConcept C55493867 @default.
- W2372965651 hasConcept C62112901 @default.
- W2372965651 hasConcept C71924100 @default.
- W2372965651 hasConcept C86803240 @default.
- W2372965651 hasConcept C98274493 @default.
- W2372965651 hasConceptScore W2372965651C109541995 @default.
- W2372965651 hasConceptScore W2372965651C121608353 @default.
- W2372965651 hasConceptScore W2372965651C126322002 @default.
- W2372965651 hasConceptScore W2372965651C153911025 @default.
- W2372965651 hasConceptScore W2372965651C185592680 @default.
- W2372965651 hasConceptScore W2372965651C202751555 @default.
- W2372965651 hasConceptScore W2372965651C2777752497 @default.
- W2372965651 hasConceptScore W2372965651C2778019345 @default.
- W2372965651 hasConceptScore W2372965651C2778695046 @default.
- W2372965651 hasConceptScore W2372965651C2779707156 @default.
- W2372965651 hasConceptScore W2372965651C2780783641 @default.
- W2372965651 hasConceptScore W2372965651C2780835546 @default.
- W2372965651 hasConceptScore W2372965651C2994423619 @default.
- W2372965651 hasConceptScore W2372965651C530470458 @default.
- W2372965651 hasConceptScore W2372965651C55493867 @default.
- W2372965651 hasConceptScore W2372965651C62112901 @default.
- W2372965651 hasConceptScore W2372965651C71924100 @default.
- W2372965651 hasConceptScore W2372965651C86803240 @default.
- W2372965651 hasConceptScore W2372965651C98274493 @default.
- W2372965651 hasLocation W23729656511 @default.
- W2372965651 hasOpenAccess W2372965651 @default.
- W2372965651 hasPrimaryLocation W23729656511 @default.
- W2372965651 hasRelatedWork W2116877680 @default.
- W2372965651 hasRelatedWork W2121016625 @default.
- W2372965651 hasRelatedWork W2316589599 @default.
- W2372965651 hasRelatedWork W2347597422 @default.
- W2372965651 hasRelatedWork W2352633359 @default.
- W2372965651 hasRelatedWork W2359061821 @default.
- W2372965651 hasRelatedWork W2381859968 @default.
- W2372965651 hasRelatedWork W2386617893 @default.
- W2372965651 hasRelatedWork W2387271620 @default.
- W2372965651 hasRelatedWork W2389151301 @default.
- W2372965651 hasRelatedWork W2389960695 @default.
- W2372965651 hasRelatedWork W2390141573 @default.
- W2372965651 hasRelatedWork W2390656650 @default.
- W2372965651 hasRelatedWork W2394136490 @default.
- W2372965651 hasRelatedWork W2510359691 @default.
- W2372965651 hasRelatedWork W2993421633 @default.
- W2372965651 hasRelatedWork W3028735522 @default.
- W2372965651 hasRelatedWork W3031479433 @default.
- W2372965651 hasRelatedWork W3184310518 @default.
- W2372965651 hasRelatedWork W3184739865 @default.
- W2372965651 isParatext "false" @default.
- W2372965651 isRetracted "false" @default.
- W2372965651 magId "2372965651" @default.
- W2372965651 workType "article" @default.