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- W2372968406 abstract "Objective To investigate the intervene of Xinnaoshutong Capsules in brain microcirculation disorder in rats after cerebral ischemia and reperfusion.Methods The rat model of focal cerebral ischemia and reperfusion was established by using suture method.After 24 hours the rats were killed and the brain tissue was given HE staining.The pathomorphological changes and lesion in cortex were observed with the microscope,the levels of 6-Keto-prostaglandin F1α,(6-Keto-PGF1α) and thromboxane B2(TXB2) in injured cortex were detected by applying radioimmunoassay,and the level of fibrinogen(FIB) was determined by using thrombin method.Results In the model group there were obvious ischemia pathomorphological changes in injured cortex,such as edema of neurons and vascular endothelial cells,and microvessel lumen stenosis.The levels of 6-Keto-PGF1α and TXB2 increased abnormally(P0.05,P0.01),and plasma FIB level increased significantly(P0.01).Xinnaoshutong Capsules alleviated the pathomorphological lesion significantly,decreased the level of TXB2 and reduced plasma FIB level(P0.01,P0.05).Conclusion Xinnaoshutong Capsules alleviates cerebral lesion induced by ischemia and reperfusion and protects injured brain tissue significantly.The mechanism may be related to that Xinnaoshutong Capsules can adjust vascular activated substance,regulate the pathological changes of hemorrheology,and relieve microcirculatory disturbance." @default.
- W2372968406 created "2016-06-24" @default.
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- W2372968406 date "2009-01-01" @default.
- W2372968406 modified "2023-09-23" @default.
- W2372968406 title "Influence of Xinnaoshutong Capsules on changes of regulating activated substance of brain microcirculation in rats after cerebral ischemia and reperfusion" @default.
- W2372968406 hasPublicationYear "2009" @default.
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