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- W2372983183 abstract "AIM:To evaluate the biological effects of epidermal growth factor(EGF) and aloes on cell proliferation,and then to develop medical adhesive based compound oral pellicles to treat oral ulcer and observe its therapeutic effect.METHODS:Thiazoly blue(MTT) colorimetric assay was used at different time points(24,48 and 72h) to determine the proliferative effect after administration of EGF and aloes with different concentrations.Then oral ulcer was established in SD rats by local administration of crystal NaOH.Totally 90 rats were divided into 6 groups with 15 in each.The oral ulcer in each group was treated by saline,EGF,aoles or medical adhesive along or combination.After 3-and 7-days treatment the therapeutic effect was observed and histopathological changes were checked by HE staining.RESULTS: ①In comparison to the control group,0.1~10μg/l EGF significantly inhibited the proliferation of 3T3 cells at 24h.②During 24~72h compared with control group,aoles(1:100) significantly stimulated the proliferation of 3T3.③10μg/l EGF and aoles have important roles of cooperation or to adjust.④The treatment groups of EGF+aoles and EGF +aoles+medical adhesive effectively accelerated the healing time of oral ulcer.The healing rate of the EGF +aoles+medical adhesive group was also higher than other groups with only single administration.CONCLUSION:The compound oral pellicles by EGF,aloe and medical adhesive could promote healing of oral ulcer." @default.
- W2372983183 created "2016-06-24" @default.
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- W2372983183 date "2009-01-01" @default.
- W2372983183 modified "2023-09-22" @default.
- W2372983183 title "Effects of composite medical adhesive film in oral mucosal ulcer healing" @default.
- W2372983183 hasPublicationYear "2009" @default.
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