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- W2372986871 abstract "Objective To explore the significance of transcription factors and cytokine within bone marrow in children with acute idiopathic thrombocytopenic purpura(AITP) and chronic idiopathic thrombocytopenic purpura(CITP).Methods Bone marrow were respectively collected from 28 children with AITP、19 children with CITP and 21 comparably normal children.Percoll density gradient and immunomagnetic beads methods were used to purify megakaryocytes from bone marrow.Immune cytochemistry was used to detect GATA-1 and NF-E2 on megakaryocytes.The levels of TPO were detected by ELISA.Results Before treatment in children with AITP and CITP,the levels of GATA-1 and NF-E2 on megakaryocytes in bone marrow were both increased compared with the controls(P0.05).Moreover,the levels of GATA-1 and NF-E2 in children with CITP were much higher than that in those with AITP(P0.05).In AITP and CITP,the levels of TPO in bone marrow were both increased compared with that of the controls,and there was significant difference between AITP and CITP(P0.05),but there was no significant difference between the three groups(P0.05).Conclusion These results imply that TPO﹑GATA-1 and NF-E2 indeed have certain effect on proliferation and differentiation of megakaryocyte in children with ITP.The evaluation of the levels of them may be helpful about the differentiation of AITP and CITP in children." @default.
- W2372986871 created "2016-06-24" @default.
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- W2372986871 date "2010-01-01" @default.
- W2372986871 modified "2023-09-26" @default.
- W2372986871 title "Expression Levels of TPO in Bone Marrow and GATA-1﹑NF-E2 on Megakaryocytes in Children with Idiopathic Thrombocytopenic Purpura" @default.
- W2372986871 hasPublicationYear "2010" @default.
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