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- W2372991569 abstract "Objective:To observe the character of hippocampal synaptic structure and to study the nervous mechanism of hypomnesia in vascular dementia.Methods:Permanent occlusion of bilateral common carotid arteries of rats was used to establish the animal vascular dementic models.Rats were tested by Y type maze and Morris water maze.The changes of the hippocampal synaptic structural parameters were studied with electron microscope and morphometric analysis.Results:The volume density,surface density,specific surface and numerical density on area of Gray type I synapses in CA 1 sector of hippocampus in vascular dementic rats were decreased significantly.However,the mean profile area of synapse was increased.Moreover,the curvature of synaptic interface,the width of synaptic cleft and the thickness of postsynaptic density were decreased.Conclusion:The hypomnesia is from changes of synaptic structure and synaptic number following permanent occlusion of bilateral common carotid arteries in rats." @default.
- W2372991569 created "2016-06-24" @default.
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- W2372991569 date "2002-01-01" @default.
- W2372991569 modified "2023-09-25" @default.
- W2372991569 title "Changes of the hippocampal synaptic structural parameters in vascular dementic rats" @default.
- W2372991569 hasPublicationYear "2002" @default.
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