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- W2373007092 abstract "AIM: To investigate the relationship between polymorphism of N acetyltransferase 2 (NAT2) gene and susceptibility to colorectal cancer in Han nationality of Hebei province, China. METHODS: A case control study was performed in 83 patients with colorectal cancer and 83 control subjects. The genotypes of NAT2 were determined by polymerase chain reaction restriction fragment length polymorphism(PCR RFLP) assay. RESULTS: There was no significant differences in fast acetylator genotypes between patients and control subjects( χ 2=0.1365, P =0.7118). The frequencies of genotype Wt/M2 were higher ( χ 2= 10.2176, P =0.0014) in patients (42.2%) as compared with control subjects(19.3%). If the Odds ratio (OR) for Wt/Wt was 1, OR for genotype Wt/M2 was 3.21 (95% CI: 1.33 -7.76); OR for Wt/M1 was 0.371 (95% CI: 0.04- 3.61); OR for Wt/M3 was 0.981 (95% CI: 0.38-2.51); OR for other genotypes (Mx/Mx x=1,2,3,4) was 1.32 (95% CI: 0.53-3.29), including 1. CONCLUSION: These data suggest that genotype Wt/M2 may be a risk factor of colorectal cancer in Han nationality of Hebei province, China." @default.
- W2373007092 created "2016-06-24" @default.
- W2373007092 creator A5053068973 @default.
- W2373007092 date "2004-01-01" @default.
- W2373007092 modified "2023-09-23" @default.
- W2373007092 title "Association of polymorphism of N-acetyltransferase gene with susceptibility to colorectal cancer in Han nationality of Hebei province" @default.
- W2373007092 hasPublicationYear "2004" @default.
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