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- W2373015825 abstract "Objective To investigate the significance of pancreatic cancer cells resistance to chemoradiotherapy induces EMT.Methods Several pancreatic cancer cell lines were exposed to gemzar while radiotherapy was given at the same time.After about two weeks,when 90% pancertic cancer cells were killed,a small number of cells resistant to chemoradiotherapy was obtained,and their morphological changes were observed by microscopy;transwell test was used to detect invasiveness,and western-blot was used to detect expression of epithelial marker E-cad and mesenchymal marker vimentin.Results Pancreatic cancer cells resistance to chemoradiotherapy showed phenotypic changes consistent with EMT: spindle-cell shape,loss of polarity,and pseudopodia formation.BxPC3,jf305 and pc3 cells resistance to chemoradiotherapy exhibited an increase in migrating and invading(P﹤0.05,respectively).Pancreatic cancer cells resistance to chemoradiotherapy also had decreased expression of E-cadherin and an increase in vimentin.Conclusions Pancreatic cancer cells resistance to chemoradiotherapy can induce epithelial-mesenchymal transition(EMT),and EMT may be related to resistance of chemoradiotherapy of pancreatic cancer." @default.
- W2373015825 created "2016-06-24" @default.
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- W2373015825 date "2009-01-01" @default.
- W2373015825 modified "2023-09-28" @default.
- W2373015825 title "Pancreatic cancer cells resistance to chemoradiotherapy induces epithelial-mesenchymal transition" @default.
- W2373015825 hasPublicationYear "2009" @default.
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