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- W2373025852 abstract "Objective:To evaluate the relationship and prognostic significance of matrix metalloproteinase-9(MMP-9)、epidermal growth factor receptor(EGFR) in patients with non- small cell lung cancer(NSCLC). Methods:Immunohistochemical method (S-P) was used to detect the expression of the MMP-9、EGFR in 62 NSCLC tissues and 18 normal lung tissues. Results:The positive expression rates of MMP-9 and EGFR were 67.7%,58.1% respectively in the 62 NSCLC.Their expression levels were significantly higher than those in 18 para-cancerous normal lung tissues(P 0.005).The positive rate of MMP-9、EGFR in lung cancer were closely related to the TNM stages, pathological grades and lymph node involvement(P0.05).There was the correlation between the MMP-9 and EGFR(χ 2=6.45,P 0.05).The levels of MMP-9 and EGFR expression were associated with unfavovable prognosis. Conclusion:MMP-9,EGFR could be used as markers of malignant potential and prognosis factor of NSCLC." @default.
- W2373025852 created "2016-06-24" @default.
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- W2373025852 date "2004-01-01" @default.
- W2373025852 modified "2023-09-25" @default.
- W2373025852 title "Study on expression and relationship between MMP-9 and EGFR in NSCLC" @default.
- W2373025852 hasPublicationYear "2004" @default.
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