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- W2373034145 abstract "objective To investigate the antitumor activity of 5,7-dihydroxyl-8-nitro chrysin. Methods 50 male mice c57BL/6N bearing Lewis lung carcinoma were randomly divided into 5 groups:(1) normality saline groups, (2)CTX group, (3) 5,7-dihydroxyl-8-nitro chrysin low dose group, (4) 5,7-dihydroxyl-8-nitro chrysin medium dose group, (5) 5,7-dihydroxyl-8-nitro chrysin high dose group. All mice were sacrificed at the end. Executed subcutaneous tumors were weighted to calculate the inhibitory rate of tumor weight. The metastatic nodus in lung were counted. Results The subcutaneous tumor inhibitory rates were 56.95%,74.89%, 80.49% with 5,7-dihydroxyl-8-nitro chrysin 12.5,25.0,50.0 mg/kg respectively.The tumor metastasis inhibition rates of Lewis lung carcinoma were 63.04%,78.26% with 5,7-dihydroxyl-8-nitro chrysin 12.5,25.0,50.0 mg/kg respectively. the data have significant difference when they were compared with control group. Conclusion 5,7-dihydroxyl-8-nitro chrysin as a new flavonoid deriuatiue possessed the potent antitumor activity." @default.
- W2373034145 created "2016-06-24" @default.
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- W2373034145 date "2004-01-01" @default.
- W2373034145 modified "2023-09-24" @default.
- W2373034145 title "Synthesis and Antitumor Effect of 5,7-Dihydroxyl-8-Nitrio Chrysin" @default.
- W2373034145 hasPublicationYear "2004" @default.
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