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- W2373039487 endingPage "2063" @default.
- W2373039487 startingPage "2051" @default.
- W2373039487 abstract "Regulation of cell cycle arrest in premeiotic G2 phase coordinates germ cell maturation and meiotic cell division with hormonal and developmental signals by mechanisms that control Cyclin B synthesis and inhibitory phosphorylation of the M-phase kinase, Cdk1. In this study, we investigated how inhibitory phosphorylation of Cdk1 by Myt1 kinase regulates premeiotic G2 phase of Drosophila male meiosis. Immature spermatocytes lacking Myt1 activity exhibit two distinct defects: disrupted intercellular bridges (fusomes) and premature centriole disengagement. As a result, the myt1 mutant spermatocytes enter meiosis with multipolar spindles. These myt1 defects can be suppressed by depletion of Cyclin A activity or ectopic expression of Wee1 (a partially redundant Cdk1 inhibitory kinase) and phenocopied by expression of a Cdk1F mutant defective for inhibitory phosphorylation. We therefore conclude that Myt1 inhibition of Cyclin A/Cdk1 is essential for normal fusome behavior and centriole engagement during premeiotic G2 arrest of Drosophila male meiosis. The novel meiotic functions we discovered for Myt1 kinase are spatially and temporally distinct from previously described functions of Myt1 as an inhibitor of Cyclin B/Cdk1 to regulate G2/MI timing." @default.
- W2373039487 created "2016-06-24" @default.
- W2373039487 creator A5003934517 @default.
- W2373039487 creator A5022320085 @default.
- W2373039487 creator A5053001415 @default.
- W2373039487 creator A5053210115 @default.
- W2373039487 creator A5054023027 @default.
- W2373039487 date "2016-07-01" @default.
- W2373039487 modified "2023-10-01" @default.
- W2373039487 title "Myt1 inhibition of Cyclin A/Cdk1 is essential for fusome integrity and premeiotic centriole engagement in<i>Drosophila</i>spermatocytes" @default.
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