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- W2373046229 abstract "OBJECTIVE To develop a population pharmacokinetic(PPK)model for methotrexate given by intravenous infusion in cancer patients,and to evaluate the prediction performance of the PPK model.METHODS 276 concentrations from an index group of 61 cancer patients receiving methotrexate intravenous infusion were used to develop the base model,statistic model and covariate model,using PPK software PKBugs.The effect of body weight(WT),height(HT),age(Age),body surface area(BSA),serum creatinine concentration(Scr)and creatinine clearance(CL cr)on the PK parameters was investigated.PK parameters including clearance(CL),inter-compartment clearance(Q),central volume(V_1)and peripheral volume(V_2)were estimated.The prediction performance of the PPK model was assessed by using the concentration prediction error as the indicator.RESULTS The PK process of methotrexate infusion in cancer patients was discribed bv a linear two-compartment model.The final PPK model was as follows: LnCL=1.98±0.0096×(WT-67.8)-0.72×(Scr-1.04),LnQ=-1.39,LnV_1= 3.41,Ln V_2=1.93-0.013×(Age-42.4). The CL,Q,V_1 and V_2 of the 61 cancer patients were(7.84±2.42)L·h~(-1),(0.36±0.40)L·h~(-1),(31.46±11.03)L and(10.53±12.53)L,respectively.The inter-individual variability of CL,Q,V_1 and V_2 were 37%,129%,51%,and 115%,respectively. The prediction bias,precision and relative error of the PPK model for the 45 concentrations from the validation group were 0.097 mg·L~(-1),0.23 mg·L~(-1)and 136%,respectively.The P-value of the paired t test for the predicted concentrations and observed concentrations was 0.10,showing no statistical difference.CONCLUSION The PPK model built herein describes the PK process of methotrexate infusion in cancer patients adequately.The PK parameters are in good accordance with those in the literature.The prediction performance of the PPK model needs further assessment." @default.
- W2373046229 created "2016-06-24" @default.
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- W2373046229 date "2008-01-01" @default.
- W2373046229 modified "2023-09-26" @default.
- W2373046229 title "Population Pharmacokinetic Study of Methotrexate after Intravenous Infusion in Cancer Patients" @default.
- W2373046229 hasPublicationYear "2008" @default.
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