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- W2373050405 abstract "Objective To investigate the protective effects of human thioredoxin(hTrx) on lung ischemia/reperfusion(I/R) injury in rats and probable mechanism.Methods Eighty-four Wistar rats were randomly divided into control group(n=12),I/R group and Trx group with 36 in each.The later two groups were prepared I/R lung injury model,Trx group was given intraperitoneal injection of reorganized hTrx 0.75 mg/kg 10 mins before ischemia and reperfusion respectively.The lung tissue of three groups were taken to measure the contents of superoxide dismutase(SOD) and malondialdehyde(MDA)1,3,5 h after the reperfusion;TUNEL was used to observe detect apoptosis index(AI),and in situ hybridization(ISH) techniques was used to examine the Caspase-3 mRNA expression.Results The content of MDA,AI and the expression of Caspase-3 mRNA at every time point in the I/R group were all significantly higher than those in the control group(all P0.01),while the activity of SOD gradually increased with the time of reperfusion prolonging;the content of MDA,AI and the expression of Caspase-3 mRNA in the Trx group were all significantly lower than those in the I/R group(P all 0.01).The AI was positively correlated with the content of MDA and the expression of Caspase-3 mRNA(r=0.844,0.775,respectively;both P0.01),and negatively correlated with the SOD(r=-0.820,P0.05).Conclusions Trx can inhibit the apoptosis of lung tissues after the I/R;the mechanism may correlated with the cleaning of free radical suppressing oxidative stress reaction,down-regulating the expression of Caspase-3 mRNA." @default.
- W2373050405 created "2016-06-24" @default.
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- W2373050405 date "2010-01-01" @default.
- W2373050405 modified "2023-09-28" @default.
- W2373050405 title "Protective effects and mechanism of human thioredoxin on lung ischemia reperfusion injury in rats" @default.
- W2373050405 hasPublicationYear "2010" @default.
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