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- W2373050923 abstract "Objective:To investigate the protective effects of trichostatin A(TSA) against myocardial ischemia and reperfusion injury in rats.Method:Wistar rats were divided randomly into six groups:sham group,model group,positive control and 0.05 mg.kg-1,0.1 mg.kg-1 and 0.2 mg.kg-1 TSA groups.Animal model was made by ligating the left anterior descending coronary artery.Drug was administered five consecutive days before the operation by intraperitoneal injection.Rats were sacrificed after 30 min ischemia and 24 h reperfusion.Myocardial infarction size(MIS) was measured,the activity of superoxide dismutase(SOD) and the content of malondialdehyde(MDA)in serum were detected and myocardium HE staining results were observed.Result:Compared with model group,TSA can reduce the MIS,increase the activity of SOD and decrease the content of MDA in serum.Conclusions:TSA played a crucial role in cardioprotection against the ischemia and reperfusion injury in rats." @default.
- W2373050923 created "2016-06-24" @default.
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- W2373050923 date "2011-01-01" @default.
- W2373050923 modified "2023-09-26" @default.
- W2373050923 title "Protective Effects of Trichostatin A Against Myocardial Ischemia and Reperfusion Injury in Rats" @default.
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