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- W2373061954 abstract "Objective To analyze the outcome and the risk factors for mortality in the peritoneal dialysis(PD) patients in a single peritoneal dialysis in a period of 27 years,and to discuss the approaches to obtain a better prognosis.Methods We retrospectively analyzed patients on PD for more than one month during the period from January 1985 to December 2011 in this hospital.We collected and analyzed their outcomes,the cause of dropout from PD,demographic characteristics,laboratory data,dialysis adequacy,residual renal function,peritoneal transport characteristics,and nutritional status.Results A total of 841 patients were enrolled,of whom 431 were females(51.2%).The mean age at the begining of PD was 58.53 ± 16.67 years.The primary diseases for end stage renal disease were glomerulonephritis(52.3%),hypertension(16.6%),and diabetes(15.3%),in which glomerulonephritis was the most important primary disease.The mean peritoneal dialysis duration was 18.63 ± 20.35 months.Up to December 2011,the patients remained on PD in 246 cases(29.2%),died in 296 cases(35.2%),changed to hemodialysis in 152 cases(18.1%),treated with kidney transplant in 64 cases(7.6%),and lost for follow-up in 83 cases(9.9%).The main cause of death was cardiovascular events(41.6%),followed by infection(33.0%) including pulmonary infection(23.2%) and peritonitis(9.8%),and cerebral vascular accident(9.5%).The major reason(59.2%) changing from PD to hemodialysis was the PD associated infection,followed by functional abnormalities of peritoneal catheter(25.7%) such as occlusion and drift,and insufficient peritoneal dialysis(7.2%).Cox proportional hazards model analysis indicated that the risk factors for mortality were age(HR:1.06,P 0.01),diabetes(HR:1.88,P 0.01),change of hemodialysis to PD(HR:1.49,P 0.01),lower serum albumin(HR:2.44,P0.01),higher C-reaction protein(HR:2.07,P0.01),lower creatinine clearance rate(HR:1.89,P 0.05),and higher peritoneal transport status(HR:2.28,P 0.01).Conclusions In our peritoneal dialysis center,the major cause of dropout from PD was death,followed by the change to hemodialysis.Cardiovascular event was the most important cause of death,and PD-associated infection was the major reason for the change from PD to hemodialysis.Older age,diabetes,malnutrition,inflammation,insufficient peritoneal dialysis,higher peritoneal transport status and change of dialysis from hemodialysis to PD predicted the higher risk for all cause-death." @default.
- W2373061954 created "2016-06-24" @default.
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- W2373061954 date "2012-01-01" @default.
- W2373061954 modified "2023-09-28" @default.
- W2373061954 title "The analysis of outcome and the risk factors for mortality in peritoneal dialysis patients" @default.
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