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- W2373062425 abstract "Objective To investigate the regulation of Bim expression and induction of cell apoptosis of mutant and wild-type c-myc in non-p53-dependent pathway.Methods The mutant and wild-type c-myc genes were transfected into HCC1937 by lentivirus,a stable overexpression cell line was obtained.Uninfected and cells infected with lentivirus without carrying c-myc gene were served as blank control and infection control.Mutant and wild-type c-myc overexpressions and apoptosis in HCC1937 cells were detected by MTT and TUNEL,respectively.Results In mutant group and wild-type group,c-myc mRNA was overexpressed,the difference of Bim mRNA between mutant and wild-type group was significant(F=125.191,157.974;P0.05).The activity of cell multiplication in mutant group was stronger than that in wild-type group(F=769.64,P0.05).The apoptosis rates in mutant group and the two control groups were low,with no significant differences among them,and that in wild-type group,the apoptosis was higher than that in mutant group and the other two control groups(F=61.57,P0.05).ConclusionIn non-p53-dependent pathway,the overexpression of wild-type c-myc obviously up-regulates and induces cell apoptosis.This action will lose after mutation of c-myc,and it increases oncogenicity." @default.
- W2373062425 created "2016-06-24" @default.
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- W2373062425 date "2012-01-01" @default.
- W2373062425 modified "2023-09-28" @default.
- W2373062425 title "EFFECTS OF MUTANT AND WILD-TYPE c-myc ON Bim EXPRESSION IN NON-p53-DEPENDENT PATHWAY" @default.
- W2373062425 hasPublicationYear "2012" @default.
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