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- W2373063386 abstract "Objective:AngiotensinⅡ(AngⅡ),the effectors peptide of the renin-angiotensin system,has been implied in the pathogenesis of arteriosclerosis and hypertension on various levels.AngⅡ-induced endothelial dysfunction,endothelial cell apoptosis,and lipoprotein peroxidation.AngⅡ also induces cellular adhesion molecules and decreases NO,all of which participate in the induction of an inflammatory response in the vessel wall.In addition,while all of these effects contribute to neointima formation and development of atherosclerotic lesions,AngII may also be involved in acute complications of atherosclerosis by promoting plaque rupture and a hyperthrombotic state.Accordingly,AngⅡ appears to have a central role in the pathophysiology of arteriosclerosis.Methods:Human umbilical vein was isolated and culcured.Passage 3-5 of cultured HUVECs were incubated for 2、6、9、12、24 h with 10-7 M AngII or 10-9-10-6M for 12 h.Results: Total RNA was extracted,and the expression of mRNA and protein of ICAM-1 and VCAM-1 was assessed by RT-PCR and Western Blot;While measured NO production via Griess(nitrate reductase method).Conclusions: AngⅡ could stimulate the expressions of ICAM-1 and VCAM-1 on dose or time dependant both RNA and protein.Another,AngⅡ could decrease NO production on dose." @default.
- W2373063386 created "2016-06-24" @default.
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- W2373063386 date "2007-01-01" @default.
- W2373063386 modified "2023-09-28" @default.
- W2373063386 title "AngII Stimulates Adhesion Molecules and reduces the production of NO in HUVECs" @default.
- W2373063386 hasPublicationYear "2007" @default.
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