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- W2373085990 abstract "Objectives : To study endothelin 1 receptor in a rabbit model partial bladder outlet obstruction(BOO). Methods :We used the rabbit model of partial bladder outlet obstruction to study endothelin 1 receptor(ET 1R) with radioligand binding assay of receptors (RBA).Partial bladder outlet obstruction was induced in adult male New Zealand white rabbits(ten rabbits as experiment group,time of obstruction for six weeks).Sham operated age matched rabbits acted as control(ten rabbits as control group,time of postoperation for six weeks). Results: The endothelin 1 binding sites were significantly increased in the BOO detrusor smooth muscle( P 0.02).However, there was no changes in the BOO bladder neck . BOO bladder weights were significantly increased( P 0.001). Conclusions: The endothelin 1 binding sites were significantly increased in the BOO detrusor smooth muscle . Endothelin 1 has mitogenic and potent contractile properties for smooth muscle cells,has mitogenic property for connective tissue.This suggests the up regulation of ET 1R is associated with altered bladder structure and disfunction of rabbit partial bladder outlet obstruction ." @default.
- W2373085990 created "2016-06-24" @default.
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- W2373085990 date "2003-01-01" @default.
- W2373085990 modified "2023-09-25" @default.
- W2373085990 title "Studies on endothelin-1 receptor in a rabbit partial bladder outlet obstruction" @default.
- W2373085990 hasPublicationYear "2003" @default.
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