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- W2373086945 abstract "Objective To study the molecular mechanism of quinolone resistance in P.aeruginosa in Guangzhou area.Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing method was used for detecting the mutations in the gyrA,parC,gyrB,and parE genes.The dilution method was used to determine the minimum inhibitory concentration (MIC) with or without the efflux pump inhibitor carbonylcyanide-pchlorophenyl hydrazone (CCCP).The outer membrane proteins were analyzed by SDS-PAGE.Results gyrA mutations (mostly Thr-83-Ile) could be observed in 72.7% (72/99) strains,and parC mutations (mostly Ser-87-Leu) were identified in 25.3% (25/99) strains,while mutations in gyrB or parE were relatively infrequent.The MlC of 53.3% (53/99) strains were reduced significantly by adding CCCP.7%(7/10) of all the high level quinolone resistance strains showed increased expression of outer membrane proteins between 43-67 kDa.Conclusion The mutation of two types of topoisomerases and efflux pump may be the mainly causes of quinolone resistance in P.aeruginosa." @default.
- W2373086945 created "2016-06-24" @default.
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- W2373086945 date "2010-01-01" @default.
- W2373086945 modified "2023-09-25" @default.
- W2373086945 title "Study on the Mechanisms of Quinolone Resistance in Pseudomonas aeruginosa" @default.
- W2373086945 hasPublicationYear "2010" @default.
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