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- W2373111337 abstract "Objective This study sought to study the effect of the adoptive transfer of dendritic cells(DCs) during Schistosoma japonicum infection on CCL-11 and IL-13Rα2 expression and Eos infiltration in OVA-induced lung tissue cells.Methods Twenty BALB/c mice were randomly divided into a normal control group,an induced asthma group(OA group),an induced asthma group receiving DCs of mice infected with S.japonicum(ODA/SJDC group),and an induced asthma group receiving DCs of naive mice.Mice were sacrificed 24 hours after the last nasal feeding.The left lung was removed for HE staining and immunohistochemistry staining,inflammatory changes were observed,and levels of CCL-11 and IL-13Rα2 expression were detected in lung tissue.Results HE staining indicated that the OVA/SJDC group had slight inflammation while the OVA and OVA/NDC group had serious inflammation and a large number of infiltrating inflammatory cells.Immunohistochemistry staining indicated that the average optical density of CCL-11-positive regions in mouse lung tissue was 0.387 4±0.023 6 for the OVA group,0.254 6±0.017 2 for the OVA/SJDC group,and 0.316 0±0.023 5 for the OVA/NDC group.The average optical density of IL-13Rα2-positive regions in mouse lung tissue was 0.401 4±0.013 0 for the OVA group,0.280 8±0.010 2 for the OVA/SJDC group,and 0.326 6±0.014 4 for the OVA/NDC group.The difference in optical density between groups was statistically significant(P0.05).ConclusionDCs from mice infected with S.japonicum can inhibit the OVA-induced expression of CCL-11 and IL-13Rα2 and treat asthma." @default.
- W2373111337 created "2016-06-24" @default.
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- W2373111337 date "2010-01-01" @default.
- W2373111337 modified "2023-09-23" @default.
- W2373111337 title "The effect of the adoptive transfer of dendritic cells from mice infected with Schistosoma japonicum on OVA-induced CCL-11 and IL-13R_(α2)" @default.
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