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- W2373114117 abstract "Objective To observe the influences of Dingguier umbilical paste,oral Dingguier and combined medication on spleen-stomach deficiency-cold in juvenile rats.Methods A total of136SD rats were randomly divided into 11groups:normal control group,model control group,model vehicle group,small-dose Dingguier umbilical paste group,medium-dose Dingguier umbilical paste group,large-dose Dingguier umbilical paste group,Xiangshaliujun pill+small-dose Dingguier umbilical paste group,Xiangshaliujun pill+medium-dose Dingguier umbilical paste group,Xiangshaliujun pill+large-dose Dingguier umbilical paste group,Xiangshaliujun pill group,and oral Dingguier group,with 12or 13rats in each group.Spleen-stomach deficiency-cold was induced by vinegar feeding.Body weight,food intake,gastric acid secretion,gastric acidity,pepsin activity,gastric emptying rate and small intestinal propulsion rate were measured in all the 11groups.In addition,plasma levels of cholecystokinin octapeptide(CCK-8)and motilin(MTL)were determined by ELISA.Results Compared with normal control group,body weight,small intestinal propulsion rate and MTL levels were decreased but gastric acid and pepsin secretion was not changed in model control group,suggesting that rats with spleen-stomach deficiency-cold had gastrointestinal motility disorders.Compared with model control group,body weight was improved in medium-dose Dingguier umbilical paste group,and plasma CCK-8levels were decreased in Xiangshaliujun pill+medium-dose Dingguier umbilical paste group 14days after model establishment(P0.01).However,compared with model control group,body weight in other groups and gastric emptying rate and small intestinal propulsion rate in rats treated with Dingguier were not changed significantly(P0.05).Compared with normal control group,plasma MTL levels decreased in model control group and model vehicle group,but increased in small-dose Dingguier umbilical paste group(P0.05).Conclusion Dingguier umbilical paste and combined medication can regulate the secretion of gastrointestinal hormones and improve the symptoms of spleen-stomach deficiency-cold in juvenile rats." @default.
- W2373114117 created "2016-06-24" @default.
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- W2373114117 date "2014-01-01" @default.
- W2373114117 modified "2023-09-27" @default.
- W2373114117 title "Influences of Dingguier Umbilical Paste and Combined Medication on Spleen-Stomach Deficiency-Cold in Juvenile Rats" @default.
- W2373114117 hasPublicationYear "2014" @default.
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