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- W2373121036 abstract "Objective To determine the fasting and postprandial serum level of TNF-α,IL-6 in type 2 diabetes mellitus(T2DM) and to investigate their correlation with insulin resistance.Methods Thirty-five patients of T2DM and thirty nondiabetic persons were included in the study.Fasting plasma glucose(FPG), fasting insulin(FIns),TNF-α,IL-6,total cholesterol(TC),triglyceride(TG) were measured in both groups.Postprandial blood glucose,insulin,TNF-α,IL-6 were measured in the T2DM group.Results The levels of HOMA-IR,serum TNF-αand IL-6 in T2DM group were significantly higher than those in the control group(P0.01 or0.05).The level of postprandial TNF-α,IL-6 tended to increase,but the change was not significant(P0.05 ).Pearson correlation analysis showed that TNF-αwas positively correlated to FBG,HOMA-IR and TG in T2DM group(P0.01).There was also a positive correlation between TNF-αand FINS in T2DM group(P0.05).There was no correlation between IL-6 and other parameters(P0.05).Conclusion The serum levels of TNF-αand IL-6 of T2DM patients were significantly higher than those in the nondiabetic persons.TNF-αwas involved in insulin resistance.Postprandial brief elevation of serum levels of blood glucose and insulin did not have effect on those of TNF-αand IL-6." @default.
- W2373121036 created "2016-06-24" @default.
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- W2373121036 date "2009-01-01" @default.
- W2373121036 modified "2023-09-25" @default.
- W2373121036 title "Study of Fasting and Postprandial Serum Levels of TNF-α and IL-6 in Type 2 Diabetes Mellitus" @default.
- W2373121036 hasPublicationYear "2009" @default.
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