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- W2373124313 abstract "Objective To investigate the inhibitory effects of Astragaloside Ⅳ on the proliferation of abnormal vascular smooth muscle cells (VSMCs). Methods VSMCs obtained from thoracic aorta of SD rats were cultured in vitro. The changes of cell proliferation, cell apoptosis, NO and Ca2+ concentration before and after Astragaloside Ⅳ administration in VSMCs were measured. Cell proliferation was measured with tetrazolium salt WST-1 assay. Cell apoptosis was assayed with flow cytometry through the detection of annexin V. NO and intracellular Ca2+ concentration were measured by using confocal laser scanning microscopy with diaminofluorescein diacetate and Flue-3/AM, respectively. Cell aldose reductase (AR) activity was measured with absorbent spectrum of NADPH at 340 nm. Results WST assay showed that cell proliferation induced by serum was significantly inhibited by Astragaloside Ⅳ(P0.01). Analysis on flow cytometry revealed that Astragaloside Ⅳ could enhance the apoptotic rate of VSMCs (P0.01). The AR activity of VSMCs was markedly inhibited by both Astragaloside Ⅳ and an AR inhibitor, epalrestat (P0.01). NO production was significantly enhanced after the administration of Astragaloside Ⅳ or interleukin-1β. Furthermore, Astragaloside Ⅳ increased cytosolic Ca2+ significantly. Conclusion Astragaloside Ⅳ may inhibit the proliferation of VSMCs associated with serum by inhibiting AR activity, augmenting apoptosis, and increasing the levels of cytosolic Ca2+ and NO production in VSMCs." @default.
- W2373124313 created "2016-06-24" @default.
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- W2373124313 date "2011-01-01" @default.
- W2373124313 modified "2023-09-26" @default.
- W2373124313 title "Inhibitory Activity of Astragaloside IV on Proliferation of Aorta Vascular Smooth Muscle Cells in Rats" @default.
- W2373124313 hasPublicationYear "2011" @default.
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