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- W2373140500 abstract "Objective To study antitumor and hemolytic activities of nobiliside B from the sea cucumber Holothuria nobilis Selenka and its acetylic ramification.Methods Triterpene glycoside nobiliside B was acetylated with pyridine and Ac2O in icy bath,the acetylic products were separated by multi-chromatography to afford acetoxy-nobiliside B(2).The cytotoxic activity of the glycosides against ten human tumor cell lines was evaluated with the sulforhodamione B(SRB) protein assay.Results On the basis of chemical method,spectroscopic analysis and comparison with the data of nobiliside B,the structure of compound 2 was elucidated as: 3-O-[6″-acetoxy-β-D-glucopyranosyl(1→2)-4′-O-sulfate-β-D-xylopyranosyl]-holosta-9-ene-22,25-epoxy-3β,17α-diol-sodium salt.The bioassay results showed that the hemolytic activity of compound 2 was significantly decreased,while the antitumor activity was kept.Conclusion One novel acetoxy compound with high antitumor activitiy and less side effect was obtained by structure modification of nobiliside B,and should be study as a new potential antitumor drug." @default.
- W2373140500 created "2016-06-24" @default.
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- W2373140500 date "2009-01-01" @default.
- W2373140500 modified "2023-09-24" @default.
- W2373140500 title "Antitumor effects of nobiliside B from sea cucumber Holothuria nobilis and its acetoxy compounds" @default.
- W2373140500 hasPublicationYear "2009" @default.
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