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- W2373142014 abstract "Objective:To establish an HPLC method for the simultaneous determination of 5-fluorouracil and its prodrug tegafur in human plasma.Method:Proteins in plasma sample were precipitated by silver nitrate(10%)af- ter addition of the internal standard.After centrifugation,the supernatant was injected for analysis by HPLC.Separa- tion was achieved on Zorbax-ODS C_(18)(4.6 mm×250 mm,5 μm)column at 45℃,and detected at 265 nm.The mobile phase consisted of 0.01 mol·L~(-1)sodium phosphate buffer(adjusted pH to 8.0 with 2 mol·L~(-1)NaOH so- lution)-methanol(97:3)at a flow rate of 1.0 mL·min~(-1).Results:The linear ranges(n=7)for determination of 5-fluorouracil and tegafur were 0.1-20 μg·mL~(-1)(r=0.9998)and 0.2-40 μg·mL~(-1)(r=0.9998),respec- tively.The detection limits of the assay were 5,10 ng·mL~(-1),respectively.The method recoveries were 97.2%- 101.3% and 98.3%-102.6%,respectively;intra-day RSD and inter-day RSD were less than 6%.Conclu- sion:This method is sensitive,convenient,accurate,and is ideally suited for the therapeutic monitoring of 5-flu- orouracil and its prodrug tegafur." @default.
- W2373142014 created "2016-06-24" @default.
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- W2373142014 date "2007-01-01" @default.
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- W2373142014 title "Simultaneous HPLC determination of 5-fluorouracil and its prodrug tegafur in human plasma" @default.
- W2373142014 hasPublicationYear "2007" @default.
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