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- W2373155287 abstract "Objective:To determine the relationship between expression of nuclear factor kappa B(NF-κB),interleukin-8(IL-8) and cytotoxin-associated protein A(CagA),and evaluate the clinical implication of CagA in tumorigenesis and progression of gastric carcinoma.Methods:Tissue specimens from 54 cases of chronic gastritis and 58 cases of gastric cancer were evalutaed for the expression of CagA,NF-κB and IL-8 by immunohistochemistry and western blot.The relationship between NF-κB,IL-8 and CagA were detected by correlation analysis.Results:There was no difference in positive rate of CagA protein between chronic gastritis and gastric cancer groups(53.7% vs 62.1%,P 0.05).The positive rate of NF-κB and IL-8 were significant higher in peri-cancer tissues of gastric cancer than that in chronic gastritis(P 0.05).In the peri-cancer tissues of gastric cancer,the expression of NF-κB and IL-8 were significant higher in CagA positive group than that of CagA negative group(P 0.05).And there was a positive correlation between the expression of NF-κB,IL-8 and CagA.Conclusion:CagA protein might be important in tumorigenesis and progression of gastric carcinoma by up-regulating the expression of NF-κB and IL-8." @default.
- W2373155287 created "2016-06-24" @default.
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- W2373155287 date "2010-01-01" @default.
- W2373155287 modified "2023-09-25" @default.
- W2373155287 title "The expression of NF-κB,IL-8 and CagA in the peri-cancer tissues of gastric cancer" @default.
- W2373155287 hasPublicationYear "2010" @default.
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