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- W2373157329 abstract "OBJECTIVE:To evaluate the effect of compound Danshen dripping pills plus atorvastatin on urine microalbumin(mALB) in patients with early hypertensive renal disease.METHODS: A total of 116 patients with early hypertensive renal disease were randomized to either treatment group or control group,with 51 cases in treatment group and 46 in the control group included in our final evaluation.Both groups were routinely given amlodipine tablet at a dosage of 5-10 mg·d-1,however,the treatment group received add-on atorvastatin 10 mg·d-1 plus compound Danshen dropping pills(10 pills each time tid).Determination of microalbumin(mALB),immunoglobulin G(IgG),alpha 1 microglobulin(α1-MG) and beta 2 microglobulin(β2-MG) in urine were scheduled at 0 and 6 months and after the completion of the treatment followed by evaluation of curative efficacy.RESULTS: For patients with early hypertensive renal disease,the effective blood pressure control was associated with lower positive detection rate of mALB,α1-MG and β2-MG contents in urine.Among the indexes,only the reduction of β2-MG positive detection rate showed statistical differences(P0.05),whereas the reductions for all the other indexes showed no significant difference.The addition of compound Danshen drop pill plus small dose atorvastatin to blood pressure control therapy was associated with further reduction of mALB,α1-MG and β2-MG in urine(P0.05),much as in the reduction of mALB and β2-MG as compared with blood pressure control alone group(P0.05),and associated with further reduction of positive detection rate of mALB,α1-MG and β2-MG contents in urine,much as in the reduction of α1-MG and β2-MG(P0.01).The effective rate in the treatment group and the control group were 56.9% and 28.3%,respectively,and the differences were significant(P0.05).CONCLUSION: Compound Danshen dripping pills plus small dose of atorvastatin as an adjuvant therapy inhibited disease progression in patients with early hypertensive renal disease." @default.
- W2373157329 created "2016-06-24" @default.
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- W2373157329 date "2013-01-01" @default.
- W2373157329 modified "2023-09-25" @default.
- W2373157329 title "Effect of Compound Danshen Dripping Pills plus Atorvastatin on Urine Microalbumin in Patients with Early Hypertensive Renal Disease" @default.
- W2373157329 hasPublicationYear "2013" @default.
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