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- W2373162427 abstract "Objective To investigate the effects of statins on soluble cell adhesion molecules in serum and on the expression of adhesion molecules on leukocytes in dyslipidemia. Methods 38 patients with dyslipidemia were treated with statins for 8 weeks. Before and after the therapy, serum soluble endothelial leucocyte adhesion molecule(sELAM), soluble intercellular adhesion molecule 1 (sICAM 1), soluble vascular cell molecule 1(sVCAM 1) and the expression of L Selectin, intercellular adhesion molecule (ICAM) 1, ICAM 3 on leucocytes were examined. Serum interleukin 1β(IL 1β), tumour necrosis factor (TNF) were tested as well. Results After the treatment, sELAM (74.2±16.8) ng/ml vs (55.8±16.3) ng/ml, sICAM 1(441±110) ng/ml vs (321±92) ng/ml were reduced markedly (both P 0.01), but sVCAM 1 (582±67) ng/ml vs (547±72) ng/ml was not reduced significantly. Individual sELAM and sICAM 1 were positively correlated with TC( P 0.005 and P 0.01) and negatively with HDL C (both P 0.01). The percentages of monocytes and lymphocytes positive for L Selectin were increased (45.5±11.4)% vs (56.7±9.1)% and (15.9±7.2)% vs (23.1±5.7)%, P 0.05, P 0.01, respectively, whereas percentages of ICAM 1 positive monocytes and lymphocytes were reduced (91.1±6.1)% vs (78.3±5.0)% and (23.4±6.2)% vs (14.6±5.3)%, P 0.05 and P 0.01, respectively; mean fluorescence intensity of ICAM 3 on leukocytes was lowered, P 0.01. Serum IL 1 β was declined, and the individual change value was well correlated with the changes of percentage of L Selectin positive lymphocytes and mean fluorescence intensity of ICAM 3 (both P 0.01). Conclusion Statins could reduce serum soluble adhesion molecules, and regulate the expression of adhesion molecules on leucocytes and the production of cytokines, which was realized possiblely through modulating serum lipid." @default.
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- W2373162427 date "2001-01-01" @default.
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- W2373162427 title "The effects of statins on cell adhesion molecules in dyslipidemic patients" @default.
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