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- W2373192173 abstract "Objective To assess the correlation between abnormal metabolic changes and Wisconsin card sorted test(WCST) in patients with depression using magnetic resonance spectroscopy(MRS).Methods Twelve healthy volunteers(group 1),12 first-episode patients(group 2) and 10 recurrent patients(group 3) underwent WCST before MR examination.Localized magnetic resonance spectra were acquired in bilateral prefrontal lobe and cingulated cortex with single voxel 1-hydrogen MRS(1H-MRS).The ratio of all metabolte including N-acetyl-asparta(NAA),choline(Cho),glutamate and glutamine(Glx) were recorded,using creatine(Cr) as reference.Results Compared to group 1,Glx/Cr decreased and mIns/Cr increased in both bilateral prefrontal lobes in group 3,while Glx/Cr decreased in bilateral prefrontal lobes and mIns/Cr increased in right side in group 2.Response administered(RA),perseverative errors(PE) and non perseverative errors(NPE) were higher in group 2 and 3 in WCST.Glx/Cr of right prefrontal lobe correlated negatively with PE significantly in group 2,Glx/Cr of bilateral prefrontal lobes all correlated negatively with PE significantly in group 3.Conclusion The depressive patients have abnormal metabolic changes in bilateral prefrontal lobes as well as cognitive impairment,and glutamatergic system dysregulation may be the pathophysiologic basis of cognitive impairement in patients with depression." @default.
- W2373192173 created "2016-06-24" @default.
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- W2373192173 date "2011-01-01" @default.
- W2373192173 modified "2023-09-23" @default.
- W2373192173 title "Magnetic resonance spectroscopy observation on brain metabolic changes in patients with depression" @default.
- W2373192173 hasPublicationYear "2011" @default.
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