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- W2373201390 abstract "Objective To explore the association between BDNF Val66Met and APOE gene polymorphisms and sporadic Alzheimer's disease(sAD).Methods The polymorphisms of BDNF Val66Met and APOE gene were determined in 80 sAD patients and 86 normal controls by PCR-RFLP method.Results The polymorphisms of Val66Met was significantly associa ted with sAD risk.The odds ratio for sAD associated with the Met/Met genotype VS Val-carriers was 2.87(95%CI=1.31～6.28),while that of 4 vsnon-4 in APOE gene was 3.87(95%CI=1.91～7.88).The odds ratio for APOeE and BDNF Met-carriers was 3.95(95%CI=1.40～11.16).Conclusion BDNF Val66Met polymorohism may be an independent genetic risk factor for sAD in Chinese,and the onset of sAD is associated with the interaction of the polymorphisms of BDNF Val66Met and APOE gene." @default.
- W2373201390 created "2016-06-24" @default.
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- W2373201390 date "2009-01-01" @default.
- W2373201390 modified "2023-09-26" @default.
- W2373201390 title "Analysis of the Interaction of the Val66Met Polymorphisms of Brain-derived Neurotrophic Factor Gene and APOE Gene in Sporadic Alzheimer's Disease" @default.
- W2373201390 hasPublicationYear "2009" @default.
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