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- W2373201811 abstract "Objective: To investigate the effects of coadministration of berberine and evodiamine on cell growth,tumor necrosis factor-α( TNF-α) and interleukin( IL)-8 levels of gastric cancer cells( AGS) cells.Method: The inhibitory effect of coadministration of berberine and evodiamine on AGS cell growth was measured by MTT method. Cell cycle distributions were measured by flow cytometry. TNF-α and IL-8 contents were measured by ELISA method. Result: Coadministration of berberine( 15 μmol·L- 1) and evodiamine( 45 μmol·L- 1) triggered weaker inhibitory effect on the proliferation of AGS cells than that achieved by evodiamine alone,coadministration of berberine( 83 μmol·L- 1) and evodiamine( 1. 4 μmol·L- 1) obtained slightly better inhibitory effect on the proliferation of AGS cells than that of berberine or evodiamine alone,however,their co-administration did not obtain better cell cycle arrest than berberine or evodiamine alone. Further studies showed that,coadministration of berberine( 83 μmol·L-1) and evodiamine( 1. 4 μmol·L-1) induced the increase of TNF-α level in AGS cell culture supernatant which was superior to that triggered by usage of the two drugs alone. Berberine reduced IL-8 contents in the AGS cell culture supernatant but without significance difference,while,evodiamine could significantly enhance the IL-8 contents in AGS cells culture supernatant. Then their coadministration could significantly reduce the IL-8 levels in the AGS cell culture supernatant. Conclusion: Different doses of berberine and evodiamine combination can result in different effect on the proliferation of AGS cells. And berberine could inhibit the increase of IL-8 induced by evodiamine." @default.
- W2373201811 created "2016-06-24" @default.
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- W2373201811 date "2013-01-01" @default.
- W2373201811 modified "2023-09-24" @default.
- W2373201811 title "Effect of Coadministration of Berberine and Evodiamine on TNF-αand IL-8 Levels in AGS Cells" @default.
- W2373201811 hasPublicationYear "2013" @default.
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