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- W2373229248 abstract "Objective This randomized double-blind study compared the efficacy and side-effect profile of ketamine and morphine for Pre-emptive analgesia in 45 patients undergoing hysterectomy. Methods Forty-five patients with hysteromyoma undergone hysteromyomectomy were randomly assigned to three groups( n = 15,each group) : group C ,control group without pre-emptive analgesia; group K ,30 mg ketamine was administrated into epidural analgesia before operation; group M,1 mg morphine was administrated into epidural analgesia before operation. Postoperative analgesia was achieved in three groups by patient-controlled epidural analgesia( PCEA) with ropivacaine 0. 2% . The VAS and first PCEA trigger time ( min) ,analgetic consumption ( mg) and the number of PCEA successful triggers,analgesic-related adverse effects were observed. The changes of epinephrine ( E ) ,norepinephrine ( N E ) in plasma were detected. Results The VAS were not significantly different between group C ,K and M . The first PCEA trigger times of group K and M were longer than that of group C . The number of PCEA successful triggers and analgetic consumptions two days after operation in group K and M were significantly less than those in group C ; the levels of E and NE in plasma were increased in group K and M one day after operation and in groupC during 48 hours after operation( P 0. 05) ,but the degree in group K and M was lower than that in group C two days after operation( P 0. 01) . The levels of E and NE were not significantly different between group K and M. Conclusion The pre-emptive analgesia of ketamine or morphine can decrease analgetic consumption and stress response time. There were not any morphinerelated adverse effects in group K. And the efficacy of ketamine for Pre-emptive analgesia was better than morphine." @default.
- W2373229248 created "2016-06-24" @default.
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- W2373229248 date "2010-01-01" @default.
- W2373229248 modified "2023-09-28" @default.
- W2373229248 title "A comparison of ketamine and morphine for Pre-emptive analgesia effects and stress response after hysterectomy" @default.
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