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- W2373235601 abstract "Objective To investigate the allele frequency distribution of UDP-glucuronosyl- transferase(UGT)1A7 gene and its association with risk of colorectal cancer(CRC)in Chinese.Meth- ods One hundred and forty cases of CRC and 280 controls matching from the same follow-up cohort population established in 1989 were enrolled.The polymerase chain reaction(PCR)-based genotyping techniques including semi-nested PCR,allele-specific PCR and PCR-restriction fragment length polymor- phism(RFLP)were used for analysis of UGT1A7 polymorphism.Results The variant allele frequency in CRC cases was significantly higher than that in controls(50.0% and 38.6%,respectively).On vari- ant genotypes analysis,the frequency of variant homogenotes in CRC patients(28.6%)was also signifi- cantly higher than that in controls(14.3%),which exhibited a significant association with CRC risk(OR =2.74,95%CI:1.54～4.88).The tendency tested by likelihood ratio suggested that the increase of risk had statistical significance(χ=12.15,P=0.00).As for the environmental exposure factors,the fried or smoked-dried meat consumption was associated with CRC,and the risk increased significantly in moderate(≤14.35 kg/year)and high (＞14.35 kg/year)intake groups compared with that in low intake(≤5.40 kg/year) group (P=0.02,OR=1.84,95%CI:1.09～3.11).Stratification analysis by environmental factors found only in previous-current cigarette smoking individuals or in previous- current alcohol drinking individuals,the variants were significantly associated with CRC(OR=3.13, 95%CI:1.03～9.52,OR=2.89,95%CI:0.99～8.46,respectively).Conclusions UGT1A7 poly- morphisms was positively related with occurance of CRC,which also exerted a synergetic effects with environmental factors,cigarette smoking and alcohol consumption." @default.
- W2373235601 created "2016-06-24" @default.
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- W2373235601 date "2006-01-01" @default.
- W2373235601 modified "2023-09-26" @default.
- W2373235601 title "The association of genetic polymorphisms of UDP-glucuronosyltransferase 1A7 gene with colorectal cancer in Chinese" @default.
- W2373235601 hasPublicationYear "2006" @default.
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