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- W2373244018 abstract "Objective Safety and immunological effect of Mycobacterium vaccae for injection on tuberculosis prevention was evaluated in older non-tuberculosis children.Methods Healthy children(5-9 years old) were divided into PPD positive group and PPD negative group.Each child in two groups was received 3 doses Mycobacterium vaccae for injection at 2 weeks interval.Blood samples were collected before vaccination and 1 month later after third injection.Lymphocyte,Th cells,Ts cells and T Iymphocyte were counted by FCM,and adverse reactions of vaccination were inspected.Results No any adverse reaction was observed during vaccination.The number of Lymphocyte,The cells,Ts cells and T lymphocyte were significantly increased in PPD negative group(P0.05.90 percent of cell counts increase was above 2 SD with 92%-96% increase rate.The number of Lymphocyte,Th cells were significantly increased in PPD positive group(P0.05 with nearly 70% increase rate.Conclusions The results showed that Mycobacterium vaccae vaccination is safe and effective on improving cellular immune function in PPD negative and PPD positive children,and suggested that Mycobacterium vaccae for injection is a valuable candidate vaccine for tuberculosis prevention in older children,which could replace BCG re-inoculation." @default.
- W2373244018 created "2016-06-24" @default.
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- W2373244018 date "2006-01-01" @default.
- W2373244018 modified "2023-09-23" @default.
- W2373244018 title "Safety and Immunological Effect of Mycobacteriun Vaccae for Injection on Tuberculosis Prevention" @default.
- W2373244018 hasPublicationYear "2006" @default.
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