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- W2373247471 abstract "To discuss the effects of nitric oxide(NO)on endothelin(ET)stimulating hypertrophy and expression of myosin heavy chain(MHC) genes in cultured rat cardiomyocytes.Method:120 large rate were divided into 11 groups.The effect of NO were observed by measuring the diameter and number of cardiomyocytes,incorrporation of 〔 3H〕leucine and dot blot hybridization.Result:The number of cardiomyocytes in both NO group and ET group had no significant (P 0.05 ) difference from that of control group,ET significantly (P 0.01 ) increased the diameter of cardiomyoctes by ( 34.5 ± 5.5 )%.NO difference was found between the diameter of cardiomyocytes in NO group ( 6.2 ± 2.5 )% and control group.NO significantly (P 0.01 ) inhibited ET stimulating 〔 3H〕leucine uptake.ET induced switching of MHC gene expression with increases in β MHC mRNA and decreases in α MHC mRNA,which was reversed by NO.Conclusion: NO can inhibit ET promoting cardiomyocyte hypertrophy and reverse the pathologic switching of MHC isoform mediated by ET." @default.
- W2373247471 created "2016-06-24" @default.
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- W2373247471 title "Effects of nitric oxide on endothelin stimulating hypertrophy and expression of myosin heavy chain genes in cultured rat cardiomyocytes" @default.
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