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- W2373247512 abstract "Objective:To observe the efficacy of microcapsules to prolong islet xenografts survival in mice.Methods:Human fetal pancreatic islets were isolated from the embryo which was obtained from legal abortion(gestational age 16～24 weeks) with collagenase and enclosed in semipermeable alginate BaCl 2 capsules.Diabetic BALB/ C mice induced with streptozotocin were divided into 3 groups.Each group had 7 mice.Then transplantation was performed.Results:Transplantation of 1000±100 encapsulated fetal islets into the peritoneal cavities of 7 BALB/ C mice restord normalglycemia for 78.4±21.27 days without immunosuppression.The second group of 7 diabetic mice received an equal number of uncultured pancreatic fragments.These unprotected xenografts were functional for only 7.43±3.42 days,but high mortality occured.There was significant differences between the two groups(P0.001).The 7 mice that received only empty capsules showed continuous hyperglycemia and high motality.There was no spontaneous diabetic remission among these animals.Conclusion:These results demonstrate that the semipermeable membranes can protect the islets from immune injuries and transplants of microencapsulated islets can effectively prolong xenograft survival without immunosupression." @default.
- W2373247512 created "2016-06-24" @default.
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- W2373247512 date "2002-01-01" @default.
- W2373247512 modified "2023-09-23" @default.
- W2373247512 title "Xenograft of microencapsulated human pancreatic islets to diabetic mice" @default.
- W2373247512 hasPublicationYear "2002" @default.
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