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- W2373251211 abstract "Objective To probe into the development trends of post-stroke mental symptoms based on the changes of post-stroke mental symptom group in rats and the interventional effect of Yi Nao Jie Yu Fang with the actions of replenishing kidney and regulating qi.Methods Male Wistar rats,after open-field ethology scoring,were randomly divided into the normal group,sham-operation group,multiple cerebral infarction(MCI) group,Chinese medicinal group,Western medicinal group,post-stroke depression(PSD) group and vascular dementia(VD) group.The normal group was fed normally,sham-operation group was injected normal saline solution(0.3 mL) through the external carotid artery and given distilled water intragastrically,and other groups were injected homogenous heterophile thromboembolus through the external carotid artery by using the injection of homogenous microembolus in vitro.The Chinese medicinal group was given Yi Nao Jie Yu Fang and Western medicinal group was given nimodipine all for 4 weeks after modeling.After the operation for 7 days,the PSD group was given chronic unpredictable mild stress(CUMS) and isolation rearing for 21 days for duplicating PSD model.After the operation for 28 days,the VD group was selected by Morris water maze and then put into the test.On the 4th week after successfully modeling,the characterization observation was carried out in rats including the changes of hair and eyes,average food intake and body weight.At the same time the ethological detection was conducted including consumption test of sucrose water,open-field test,and test of shuttle box.Results The characterization observation showed that the average food intake decreased in the MCI group,PSD group and VD group,especially in the latter two groups,and the change trend of body weight was similar.The ethological detection showed that the interest and ability of memory decreased significantly in the MCI group,PSD group and VD group.The consumption test of sucrose water and open-field test indicated that decrease was mainly in interest in the PSD group and the test of shuttle box active avoidance response indicated that decrease was mainly in ability of memory and learning in the VD group.Chinese medicinal slowed the decrease trends of characterization and ability of memory and learning.Conclusion There are changes of mental symptom group in rats after cerebrovascular diseases and treads of developing to PSD and VD.Yi Nao Jie Yu Fang can slowdown this development." @default.
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- W2373251211 date "2011-01-01" @default.
- W2373251211 modified "2023-09-24" @default.
- W2373251211 title "Changes of post-stroke mental symptom group and interventional effect of Chinese medicinal in rat model" @default.
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