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- W2373254920 abstract "Objective To observe the effects of IL-10,IL-17 on biological activity of human epidermal melanocytes. Methods The melanocytes were treated with IL-10 and IL-17 of different concentration. The proliferation and apoptosis of melanocytes,the activity of tyrosinase were analyzed. Results 1 With the increased culture time,the proliferation rate of cultured human epidermal melanocytes in the presence of IL-10 at the concentration of 50μg / m L increased. When melanocytes were cultured for 48 h and 72 h,there were statistically significant differences( P 0. 01) in proliferation rate of cultured human epidermal melanocytes compared with the control group. However,with the higher IL-10 concentration the proliferation rate of melanocytes manifests a downward trend with the prolonged incubation time. When melanocytes were cultured for 48 h and 72 h,the concentration rate of melanocytes in the presence of IL- 10 at the concentration of 200 ng / ml has significant differences compared with the control group( P 0. 05).2 With the increased incubation time,the inhibitory ratio of melanocytes was increased in a dose-dependent manner in the presence of IL-17.The inhibitory ratio of melanocytes between the IL-17 groups and the control group were significant difference( P0. 05) at the concentration of 50μg / ml and statistically significant( P 0. 01) at the concentration of 100μg / ml and 200μg / ml for 48 h and 72 h.3 The melanocyte tyrosinase activity of IL-10 groups increased and there are significant differences between IL- 10 groups and the control group at the concentration of50μg / ml for 48h( P0. 05). The melanocyte tyrosinase activity were inhibited in the IL-17 group,and there were significant differences between the three groups and the control group at the concentration of 50μg / ml,100μg / ml and200μg / ml for the IL-17 group. 4 Melanocytes were cultured at the concentration of 100μg / ml of IL-10,IL-17 and control group for 48 h,the apoptosis rate of melanocytes were 5. 2%,32. 1% and 5. 1% respectivel. Conclusion The appropriate concentration of IL-10 would promote the proliferation of melanocytes and the tyrosinase activity. IL-17 induced injuries on melanocytes,but the mechanisms need further research and discussion." @default.
- W2373254920 created "2016-06-24" @default.
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- W2373254920 date "2015-01-01" @default.
- W2373254920 modified "2023-09-23" @default.
- W2373254920 title "Effects of IL-10,IL-17 on biological activity of human epidermal melanocytes" @default.
- W2373254920 hasPublicationYear "2015" @default.
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