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- W2373257749 abstract "Objective To investigate the clinical effects of cimetidine on hepatic metastasis and its relations with the expression of sialyl Lewis-X(SLeX) in colorectal carcinoma.Methods The expression of SLeX in colorectal carcinoma was studied by the microwave-labelled strept-avidin biotin immunohistochemical method.Eighty patients were allocated into three groups.Seventy-three patients with positive expressions of SLeX were randomly allocated into two groups.Group 1(43 cases) was given 200 mg of 5-fluorouracil orally per day together with 800 mg of cimetidine per day.Group 2(30 cases) received 5-fluorouracil alone.Group 3(7 cases) with negative expressions of SLeX was also given 200 mg of 5-fluorouracil per day orally together with 800 mg of cimetidine per day.LFP chemotherapy was administrated for Dukes C patients.The treatment was initiated 3 weeks after the operation and terminated after one year for all patients.A mean follow-up term was 10.4±2.6 years.Results The total 10-year hepatic metastasis rate detected by B ultrasound and or CT was 33.8%(27/80),whereas it was 20.9%(9/43) in group 1,53.3%(16/30) in group 2,and 28.6%(2/7) in group 3 respectively.Hepatic metastasis rate as shown above between group 1 and group 2 was remarkably significant(P0.05),whereas that between group 1 and group 3 or between group 2 and group 3 was not significant.Twenty-one patients with metastasis underwent hepatic resection.The positive expression rate of SLeX was 89.5%(17/19) in hepatic metastastic focus of group 1 plus group 2.The expression of SLeX was negative(0/2) in hepatic metastastic focus of group 3.The 1-year survival rates of group 1,group 2 and group 3 were 71.4%(5/7),41.7%(5/12) and 50.0%(1/2) respectively after hepatic resection and continuing treatment.There were not significant among the three groups.Conclusions Cimetidine administration can dramatically prevent hepatic metastasis and improve the survival rate of patients with advanced colorectal cancer with cells of high expressing levels of SLeX." @default.
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- W2373257749 date "2009-01-01" @default.
- W2373257749 modified "2023-09-28" @default.
- W2373257749 title "Cimetidine prevents hepatic metastasis of colorectal cancer and its value" @default.
- W2373257749 hasPublicationYear "2009" @default.
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