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- W2373266475 abstract "[Purpose]To investigate the silver lining of cancer biological-therapeutic regimen.The hepatic carcinoma cell line Bel7402-V3 intervened with combination of monoclonal antibodies 15D2 and 9A9 to monitor its subsequent functions change including self-renewal,invading and drug-resis- tance abilities. [Methods]Hepatic carcinoma cell line Bel7402-V3 was choose as an ideal model,in which living cell flow cytometry was adopted to identify the expression of sole antibody,combination antibodies and cancer stem cell marker among parent cells and spheres. Antibodies' s influence on cell self-renewal,invade ability and drug-resistance were examined by methyl cellulose spheres, Transwell invading test and CCK8 plus IC50 method respectively. [Results] The proportion of cells identified by cancer stem cell marker ESA,9A9A and 15D2 in the sphere cells were enriched 2.6 times,2.0 times and 4.1 times more than those in the parental cells,respectively. The co-expression antigen of combined antibodies and ESA was more than the sum of antigen located on(9A9+ESA) and(15D2 +ESA).The combined antibodies have notable inhibitory ratio than sole antibody with equal concentration on spheres forming and invading ability,which is same as drug-resistance. The IC50 in combined antibodies group,9A9 and 15D2 was 0.32μg/ml,0.58μg/ml and 0.56μg/ml,respectively. [Conclusion]There are different kinds of sub-sets in cancer stem cells bearing distinct functions on many signal pathways and gene expression. Combined multi-targeted antibodies are capable of in- creasing efficacy of treatment." @default.
- W2373266475 created "2016-06-24" @default.
- W2373266475 creator A5061726823 @default.
- W2373266475 date "2014-01-01" @default.
- W2373266475 modified "2023-10-03" @default.
- W2373266475 title "The Efficacy of Combined Multi-targeted Cancer Stem Cell Therapy" @default.
- W2373266475 hasPublicationYear "2014" @default.
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