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- W2373276144 abstract "Objective:To investigate the changes of vascular endothelial function in early diabetic retinopathy patients and the effect of compound Danshen droppills on intervention.Method:Fixty-five patients with early diabetic retinopathy were selected and divided into two groups(routine group and Danshen droppills group).routine group was treated with insulin;the Danshen droppills group was was treated with Compound Danshen droppills(10# Tid)combined with insulin.31 healthy as control group.After 8 weeks treatment,the endothelium-dependent flow-mediated dilatation(FMD) of brachial artery was determined with ultrasound,and the levels of fasting blood glucose(FBG),glycosylated hemoglobin(HbA1c),cholesterol(TC),triglyceride(TG),high sensitivity C-reactive protein(hs-CRP),intercellular adhesion molecule-1(ICAM-1)and endothelin-1(ET-1) in three groups were measured respectively before and after treatment.The change of fluorescein angiography in early diabetic retinopathy patients were observed before and after treatment.Result:All patients with early diabetic retinopathy showed that the FBG,HbA1c,TC,TG,hs-CRP,ICAM-1 and ET-1 was higher than that of the controlled group(P0.05),the FMD was lower than the controlled group(P0.05).After treatment fundus fluorescence angiography in Danshen droppills group was obviously improved than befor therapy,the hs-CRP,ICAM-1,ET-1 in the Danshen droppills group[(8.76±1.26)mg·L-1,(407.82±87.45) μg·L-1,(96.68±10.69) ng·L-1] was decreased more significantly than routine group[(18.78±2.42)mg·L-1,(597.79±60.74) ng·L-1,(184.5±10.78) ng·L-1](P0.05).After treatment the FMD in the Danshen droppills group was increased more significantly than routine group [(11.88±3.57)% vs(9.17±0.54)%](P0.05).Conclusion:The compound Danshen droppills can effectively reduce the body's inflammationrecovery and recovery vascular endothelial function in patients with early diabetic retinopathy." @default.
- W2373276144 created "2016-06-24" @default.
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- W2373276144 date "2013-01-01" @default.
- W2373276144 modified "2023-09-24" @default.
- W2373276144 title "Effect of Compound Danshen Droppills on Vascular Endothelial Function in Early Diabetic Retinopathy Patients" @default.
- W2373276144 hasPublicationYear "2013" @default.
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